Mitochondrial Effects of C18:0 Supplementation in Humans
Mitochondrial Effects of C18:0 Supplementation in Humans
NCT ID: NCT02957838 Phase: NA Status: COMPLETED Enrollment: 23 Completion: 2017-11-18
Conditions
Alteration of Mitochondrial Membrane, Type2 Diabetes, Fatty Acid Deficiency
Interventions
C18:0, mock
Summary
The purpose of this crossover study is to determine whether nutritional supplementation of C18:0 in humans has mitochondrial effects as shown in Drosophila and human cell culture. We will compare a study cohort of patients with diagnosed type 2 diabetes with non-diabetics. Participants will undergo a 2-day low-fat vegan diet and will then be supplemented with a bolus of C18:0. Changes in the mitochondrial morphology and function of white blood cells will be scored by immunofluorescence and FACS analysis.
Primary Outcome
Changes in Mitochondrial Morphology