Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest
Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest
NCT ID: NCT02834065 Phase: NA Status: COMPLETED Enrollment: 273 Completion: 2023-02
Conditions
Cognition Disorders
Interventions
Cardiopulmonary bypass machine
Summary
In this study the investigator will randomize 273 subjects to deep (\<20°C), low (20.1°C-24°C), or moderate (24.1°C-28°C) hypothermia during aortic arch surgery with circulatory arrest. The primary purpose of this study is to determine the effect of deep vs low vs moderate hypothermia on neurocognitive function, brain functional connectivity, and leukocyte SUMOylation patterns after surgical circulatory arrest in participants.
Primary Outcome
Change in short-term cognition as measured by continuous cognitive score