Medically-Graded Honey Supplementation Formula To Preterm Infants
Medically-Graded Honey Supplementation Formula To Preterm Infants
NCT ID: NCT02679183 Phase: EARLY_PHASE1 Status: COMPLETED Enrollment: 40 Completion: 2014-03
Conditions
Prebiotics, Honey, Premature Infants, Intestinal Microbiota
Interventions
Medically-Graded Honey, Premature Milk Formula
Summary
Honey is a natural product that contains multiple nutrients; it is composed of fructose, glucose and fructooligosaccharides that can potentially serve prebiotic functions. It also contains more than 180 substances including amino acids, vitamins, minerals and enzymes. Investigators hypothesized that supplementation of enteral feeds with honey would produce a bifidogenic effect and stimulate the immune response in preterm infants. Investigators randomly assigned subjects to 4 groups receiving 0, 5, 10 and 15 grams of honey daily for 2 weeks and measured their effect on stool colonization, systemic immune parameters and anthropometric measurements.
Primary Outcome
The presence of Bifidobacterium bifidum and Lactobacillus spp in Stool