Lower Third Molar Removal With 2% and 4% Articaine
Lower Third Molar Removal With 2% and 4% Articaine
NCT ID: NCT02457325 Phase: PHASE4 Status: COMPLETED Enrollment: 50 Completion: 2012-12
Conditions
Impacted Third Molar Tooth, Adverse Reaction to Other Local Anesthetics
Interventions
Surgery with 2%Articaine first, then Surgery with 4% Articaine, Surgery with 4%Articaine first, then Surgery with 2% Articaine
Summary
The present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the removal of lower third molars. Onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 50 healthy volunteers underwent removal of symmetrically positioned lower third molars, in two separate appointments (one to two months apart), under local anesthesia with either articaine 2% or 4% (both with 1:200,000 adrenaline) in a double-blind, randomized and crossed manner.
Primary Outcome
Onset of Anesthetic