n-3 Polysaturated Fatty Acids-rich Diet in Psoriasis
n-3 Polysaturated Fatty Acids-rich Diet in Psoriasis
NCT ID: NCT01876875 Phase: PHASE4 Status: COMPLETED Enrollment: 44 Completion: 2008-10
Conditions
Plaque-type Psoriasis, Obesity (Body Mass Index >30 kg/m2)
Interventions
Energy-restricted, n-3 polysaturated fatty acids-rich diet, Usual diet
Summary
Low-grade systemic inflammation associated with obesity may worsen the clinical course of psoriasis. Both a low-calorie diet and nutritional supplementation have been shown to have an impact on the clinical course of psoriasis, including an anti-inflammatory effect of n-3 polyunsaturated fatty acids (PUFAs). This study aimed to assess the effectiveness of an energy-restricted diet, enriched in n-3 PUFAs and poor in n-6 PUFAs, on metabolic markers and clinical outcome of obese patients with psoriasis.
Methods: Forty-four obese patients with mild-to-severe plaque-type psoriasis treated with immuno-suppressive drugs were randomized to assume either their usual diet or an energy-restricted diet (20 kcal/kg/ideal body weight/day) enriched of n-3 PUFAs (average 2.6 g/d). All patients continued their immuno-modulating therapy throughout the study. End-point measures included anthropometric, biochemical and clinical parameters at baseline, 3 and 6 months.
Primary Outcome
Composite outcome of Metabolic markers