Genetic Effect on Omega 3 Fatty Acids for the Treatment of Fatty Liver Disease
Genetic Effect on Omega 3 Fatty Acids for the Treatment of Fatty Liver Disease
NCT ID: NCT01556113 Phase: NA Status: COMPLETED Enrollment: 17 Completion: 2017-02
Conditions
Non Alcoholic Fatty Liver Disease, Steatohepatitis, Hypertriglyceridemia, Alanine Aminotransferase, Plasma Level of, Quantitative Trait Locus 1
Interventions
Omega diet
Summary
To explore whether there is a different response to omega-3 fatty acid rich diet with respect to the hepatic fat fraction % (HFF), triglyceride, and ALT levels between the rs738409 minor allele (GG) and the common allele homozygous (CC) of PNPLA3.
Hypothesis: We expect that subjects homozygous for the minor allele of the rs73049 SNP will lower their triglyceride, hepatic fat content, and ALT levels more with dietary intervention than the common allele homozygous supplementation.
Primary Outcome
reduction in hepatic fat fraction