N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
NCT ID: NCT01265563 Phase: PHASE2 Status: COMPLETED Enrollment: 108 Completion: 2016-12
Conditions
Diabetic Nephropathy, Proteinuria, Oxidative Stress
Interventions
N-acetylcysteine placebo and silibin placebo, N-acetylcysteine active and silibin placebo, N-acetylcysteine placebo and silibin active, N-acetylcysteine active and silibin active, N-acetylcysteine active + high-dose silibin active
Summary
The study is done to find out whether the combined use of the nutritional supplements N-acetylcysteine and Siliphos (milk thistle extract) corrects the shedding of urine protein and oxidative damage (damage to cells and organs often compared to fast aging) in patients with Type 2 Diabetes Mellitus (T2DM) and diabetic kidney disease.
Primary Outcome
Change From Baseline in Urinary Albumin Excretion