Effects of Isoflavones on Gene-expression
Effects of Isoflavones on Gene-expression
NCT ID: NCT01232751 Phase: NA Status: COMPLETED Enrollment: 30 Completion: 2011-10
Conditions
Postmenopause
Interventions
Isoflavone supplement
Summary
Alleged benefits experienced by the consumption of soy in Asian countries have been attributed to the isoflavone content of soy products. Amongst other benefits, isoflavones are believed to relieve menopausal symptoms and are therefore often consumed in supplement form in Western countries. These supplements contain relatively high amounts of isoflavones, and the question is if these concentrations still exert beneficial effects or whether negative effects become dominant. Therefore, the investigators will study the effect of intake of one dose of isoflavones, as compared to placebo, for eight weeks on gene-expression in Peripheral Blood Mononuclear Cells (PBMCs) in post-menopausal, equol-producing women.
Primary Outcome
Gene-expression measured by micro-arrays