Zinc × Penicillamine

Severity: MODERATE Evidence: well-established

Mechanism

Zinc reduces penicillamine absorption and vice versa.

Effect

Reduced efficacy of both agents

Management

Separate doses by at least 2 hours.

Source

Harkness JA, Blake DR. BMJ 1982

⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.