Vitamin D × Digoxin

Severity: MODERATE Evidence: probable

Mechanism

Vitamin D promotes calcium absorption. Hypercalcemia potentiates digoxin toxicity.

Effect

Increased risk of digoxin toxicity if hypercalcemia develops

Management

Monitor serum calcium and digoxin levels. Avoid excessive vitamin D dosing.

Source

FDA digoxin labeling; Cheung K et al. J Clin Pharm Ther 2013

⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.