Vitamin A × Retinoids

Severity: CRITICAL Evidence: well-established

Mechanism

Vitamin A and synthetic retinoids (isotretinoin, acitretin) both activate retinoid receptors. Combined use causes additive toxicity.

Effect

Hypervitaminosis A: hepatotoxicity, pseudotumor cerebri, teratogenicity

Management

Avoid vitamin A supplements with systemic retinoids. Do not exceed RDA.

Source

FDA isotretinoin labeling; Vahlquist A et al. Dermatology 2008

⚠️ CRITICAL INTERACTION: This combination should be AVOIDED.

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.