Interaction: St Johns Wort × Tricyclic Antidepressants
St Johns Wort × Tricyclic Antidepressants
Severity: MODERATE Evidence: probable
Mechanism
St. John's wort induces CYP2C19 and CYP3A4, increasing metabolism of tricyclic antidepressants.
Effect
Reduced antidepressant levels; loss of efficacy
Management
Monitor antidepressant levels. Avoid combination if possible.
Source
Roots I et al. Pharmacopsychiatry 2000
⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.
Disclaimer
This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.