Interaction: Milk Thistle × Sirolimus
Milk Thistle × Sirolimus
Severity: MODERATE Evidence: probable
Mechanism
Milk thistle inhibits CYP3A4 and P-gp, potentially increasing sirolimus levels.
Effect
Increased sirolimus levels; potential toxicity
Management
Monitor sirolimus levels closely. May need dose reduction.
Source
Mills E et al. Pharmacotherapy 2005; DiCenzo R et al. J Clin Pharmacol 2003
⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.
Disclaimer
This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.