Milk Thistle × Metronidazole

Severity: MINOR Evidence: possible

Mechanism

Milk thistle may inhibit CYP3A4 and CYP2C9, potentially increasing metronidazole levels.

Effect

Possible increased metronidazole levels

Management

Monitor for metronidazole side effects. Minor clinical concern.

Source

Gurley BJ et al. Drug Metab Dispos 2006

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.