Melatonin × Warfarin

Severity: MINOR Evidence: possible

Mechanism

Melatonin may affect CYP2C9 activity, potentially altering warfarin metabolism.

Effect

Possible minor INR changes

Management

Monitor INR if starting melatonin. Interaction is of minor clinical concern.

Source

Hermida RC et al. Chronobiol Int 2002

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.