Magnesium × Levothyroxine

Severity: MODERATE Evidence: possible

Mechanism

Magnesium may reduce levothyroxine absorption, similar to calcium.

Effect

Reduced levothyroxine absorption; hypothyroid symptoms

Management

Separate doses by at least 4 hours.

Source

Singh N et al. JAMA 2000 (extrapolated from calcium data)

⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.