L Tryptophan × Maoi

Severity: CRITICAL Evidence: well-established

Mechanism

MAOIs prevent serotonin breakdown. L-tryptophan increases serotonin production. Combined use causes massive serotonin accumulation.

Effect

Serotonin syndrome (potentially fatal)

Management

Absolutely avoid combination.

Source

FDA MAOI labeling; Sternbach H. Am J Psychiatry 1991

⚠️ CRITICAL INTERACTION: This combination should be AVOIDED.

Disclaimer

This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.