Interaction: Caffeine × Lithium
Caffeine × Lithium
Severity: MODERATE Evidence: well-established
Mechanism
Caffeine increases renal lithium clearance. Abrupt caffeine cessation can increase lithium levels.
Effect
Variable lithium levels; toxicity risk if caffeine stopped suddenly
Management
Maintain consistent caffeine intake. Do not abruptly stop or start caffeine.
Source
Mester R et al. J Clin Psychiatry 1995; Jefferson JW. Biol Psychiatry 1988
⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.
Disclaimer
This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.