Interaction: 5 Htp × Tricyclic Antidepressants
5 Htp × Tricyclic Antidepressants
Severity: MODERATE Evidence: probable
Mechanism
5-HTP increases serotonin production; tricyclics may enhance serotonin transmission. Combined risk of serotonin syndrome.
Effect
Possible serotonin syndrome
Management
Avoid combination. If used, monitor closely for serotonin syndrome symptoms.
Source
Sternberg EM et al. J Neural Transm 1981
⚠️ MODERATE INTERACTION: Monitor closely if this combination is used.
Disclaimer
This interaction record is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider before starting or stopping any supplement or medication.