[Chinese expert consensus on screening and clinical application of monoclonal immunoglobulins(2025)].

Abstract

Monoclonal immunoglobulins (M proteins) are homogeneous immunoglobulins or their fragments (such as light chains) secreted by clonal B cells or plasma cells. M protein-related diseases are a group of disorders characterized by the presence of M proteins in the blood and/or urine. M protein screening helps in early M protein-related disease detection. To enhance the early detection of M protein-related diseases, domestic hematologists have developed this consensus, which systematically introduces the current screening methods for M proteins and their clinical application scenarios to guide clinical practice.

单克隆免疫球蛋白（M蛋白）是克隆性B细胞或浆细胞分泌的同种免疫球蛋白或其片段（如轻链）。M蛋白相关疾病是一类以血和（或）尿中存在M蛋白为主要特征的疾病。M蛋白筛查有助于早期发现这类疾病。为提高M蛋白相关疾病的早期发现率，国内相关领域专家制定了本共识，系统介绍现有的M蛋白筛查方法及其临床应用范围，以指导临床实践。.