Efficacy and safety of vitamin D in tuberculosis patients: a systematic review and meta-analysis

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Efficacy and safety of vitamin D in tuberculosis patients: a systematic review and meta-analysis

Goyal et al., 2022 | Expert Rev Anti Infect Ther | Meta Analysis

Citation

Goyal Jagdish Prasad, Singh Surjit, ... Charan Jaykaran. Efficacy and safety of vitamin D in tuberculosis patients: a systematic review and meta-analysis. Expert Rev Anti Infect Ther. 2022-Jul;20(7):1049-1059. doi:10.1080/14787210.2022.2071702

Abstract

BACKGROUND: Evidence from the basic research and epidemiological studies indicates a beneficial effect of vitamin D in the treatment of tuberculosis (TB). However, the evidence from randomized controlled trials (RCTs) is inconsistent. OBJECTIVES: This systematic review and meta-analysis was performed to synthesize evidence regarding role of vitamin D versus placebo for the management of TB. MATERIALS AND METHODS: We searched PubMed and Cochrane Clinical Trial Registry for RCTs comparing vitamin D versus placebo for the treatment of TB. RCTs enrolling adult patients with TB receiving vitamin D in addition to standard treatment were included. Data were pooled using random effects model. The study was conducted according to PRISMA guidelines and protocol was registered with PROSPERO (CRD42016052841). RESULTS: Of 605 identified references, 12 RCTs were included. The overall risk of bias in included studies was low or unclear. There was no significant difference between vitamin D and placebo group for any outcomes of efficacy (time to culture conversion, time to smear conversion, rate of culture conversion, and rate of smear conversion) or safety (mortality, serious adverse events, and nonserious adverse events). CONCLUSION: Vitamin D administered with standard treatment has no beneficial effect in the TB patients as compared to the placebo.

Key Findings

Of 605 identified references, 12 RCTs were included. The overall risk of bias in included studies was low or unclear. There was no significant difference between vitamin D and placebo group for any outcomes of efficacy (time to culture conversion, time to smear conversion, rate of culture conversion, and rate of smear conversion) or safety (mortality, serious adverse events, and nonserious adverse events).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population tb receiving vitamin d
Sample Size 12
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Humans
  • Tuberculosis
  • Vitamin D
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09