Antioxidant nutrients and hemolysis in sickle cell disease

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#anemia-sickle-cell #antioxidants #erythrocytes #hemolysis #humans

Antioxidant nutrients and hemolysis in sickle cell disease

Delesderrier et al., 2020 | Clin Chim Acta | Systematic Review

Citation

Delesderrier Emília, Curioni Cíntia, ... Citelli Marta. Antioxidant nutrients and hemolysis in sickle cell disease. Clin Chim Acta. 2020-Nov;510:381-390. doi:10.1016/j.cca.2020.07.020

Abstract

Hemolysis is one of the main pathophysiological characteristics of sickle cell disease (SCD) and might cause or could be the result of oxidative stress. Antioxidants are studied in SCD due to their potential to ensure redox balance and minimize deleterious effects on erythrocyte membranes. The objective of this systematic review was to evaluate the efficacy of antioxidant nutrient supplementation on reducing hemolysis in SCD patients through randomized clinical trials. We conducted our study according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses and the Cochrane Handbook for Systematic Reviews of Interventions investigating whether antioxidants could improve the hemolytic status of SCD patients. This study included 587 articles published until April 2020. We reduced this pool to 12 articles by excluding duplicates, reviews, comments, and studies with non-human subjects. Omega-3 fatty acids, vitamin A, and zinc were the antioxidants that reportedly improved the indirect hemolysis parameters such as hemoglobin, hematocrit, mean corpuscular volume, or red blood cells. High-dose vitamin C and E supplementation worsened hemolysis, causing increased reticulocytes, lactate dehydrogenase, indirect bilirubin, and haptoglobin. More intervention studies especially high-quality controlled randomized clinical trials are needed to investigate the effects of antioxidant nutrients in reducing hemolysis in SCD.

Key Findings

More intervention studies especially high-quality controlled randomized clinical trials are needed to investigate the effects of antioxidant nutrients in reducing hemolysis in SCD.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 587
Age Range See abstract
Condition stress

MeSH Terms

  • Anemia, Sickle Cell
  • Antioxidants
  • Erythrocytes
  • Hemolysis
  • Humans
  • Nutrients

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-a

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09